Seminario de Randy Schekman, Premio Nobel de Fisiología o Medicina

El jueves 28 de mayo, a las 12:00 horas en el Salón de Actos del Instituto de Biomedicina de Sevilla (IBiS), el profesor Randy Schekman, Premio Nobel de Fisiología o Medicina, impartirá el seminario titulado:

‘Biogenesis and Function of Extracellular Vesicles’

Las contribuciones han sido decisivas para comprender los mecanismos del tráfico vesicular y la secreción celular. En los últimos años, su trabajo se ha centrado especialmente en la biogénesis y función de las vesículas extracelulares, un campo de creciente relevancia para múltiples áreas de la investigación biomédica y con importantes implicaciones en comunicación intercelular, enfermedad y medicina traslacional.

Se trata, por tanto, de una ocasión científica excepcional para toda la comunidad, con interés para investigadoras e investigadores de muy diversos ámbitos, desde la biología celular y las neurociencias hasta la inmunología, la investigación cardiovascular, la oncohematología, la genética y las enfermedades hepáticas, digestivas e inflamatorias.

Dr. Randy Schekman is a Professor in the Department of Molecular and Cell Biology, University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute. He studied the enzymology of DNA replication as a graduate student with Arthur Kornberg at Stanford University. His current interest in cellular membranes developed during a postdoctoral period with S. J. Singer at the UC San Diego. Among his awards are the Gairdner International Award, the Albert Lasker Award in Basic Medical Research and the Nobel Prize in Physiology or Medicine, which he shared with James Rothman and Thomas Südhof. He served as the Editor of the Annual Reviews of Cell and Developmental Biology and as Editor-in-Chief of the Proceedings of the National Academy of Sciences (PNAS) and eLife. Beginning in 2018, Schekman has served as the Scientific Director of “Aligning Science Across Parkinson’s Disease” a major philanthropic effort organized along with The Michael J. Fox Foundation to identify molecular and cellular mechanisms in the initiation and progression of Parkinson’s Disease (https://parkinsonsroadmap.org). Schekman’s laboratory investigates the mechanism of vesicular traffic in the secretory pathway in eukaryotic cells.

Currently the lab focuses on the unconventional secretion of extracellular vesicles and of soluble proteins, such as alpha-synuclein. The means by which alpha-synuclein is released by nerve cells may relate to the spread of pathology in Parkinson’s Disease.